Discussion The structure of an enzyme is a globular protein made up of amino acids and polymers that are linked together known as polypeptide bonds. Enzyme molecules are arcuate in a three-dimensional shape, the outside of the molecule has hydrophilic R groups (side chains) which ensure its solubility. Since enzymes are proteins, they can be damaged by high temperatures, this is known as denaturation. There are many enzymes in the body that catalyze or accelerate chemical reaction in cells that would otherwise proceed slowly to support life. They respond best to the ideal temperature of 36.7°C, as this is the normal temperature of the human body. Enzymes are all used to break down certain food molecules, and there are many types. Enzymes have a distinct shape since a certain enzyme can only react with a specific substrate. In some enzymes Co factors are required to allow them to function, for example pepsin which breaks down proteins and only works in the presence of h+, so can only function within the substrate. stomach. Enzyme inhibitors are molecules that help reduce the rate of the enzymatic reaction by altering the shape of the active site directly or indirectly and thus reducing the amount of enzyme available. Blocking enzyme activity also involves killing pathogens or correcting metabolic reactions within the human body, so many drugs used for hypertension are enzyme inhibitors, which results from the relaxation of blood vessels within of the body. (Jones, 2009) The active site is the area where the substrate and enzyme react together, allowing the substrate to fit snugly and be held in place by temporary bonds because it is the correct shape. The active site can be discussed in more depth through the theory of the lock and key which sits in the center of the paper and takes its place in the active view thus blocking the path of the substrate. This slows the activity of the enzyme. An increase in substrate concentration would cause the substrate to replace the inhibitor, thus causing a normal reaction to occur at a practical rate. (Chemguide.co.uk, 2013). In conclusion; enzymes facilitate the acceleration of the reaction, these can be used repeatedly depending on external factors such as temperature which would affect the reaction rate of the enzymes. If they have been exposed to high temperatures they cannot be reused because they will denature. Other factors that influence the enzymatic activity in terms of speed and efficiency during the reaction are the substrate concentrate and inhibitors. The model that provides a more detailed explanation of how a complex enzyme substrate is produced is the induced fit model.