Introduction Polypharmacy among the elderly is a growing concern in the US healthcare system. Patients who have comorbidities and take multiple medications are at increased risk for potential adverse drug reactions. There is a great need for nursing interventions in conducting a patient medication review, also known as a “brown bag.” When nurses obtain patient history data during a provider visit, the nurse should ask “what medications are you taking?” and the answer must also include over-the-counter medications. If the response does not include medications other than those prescribed, it is up to nurses to question the patient further to ensure no over-the-counter medications or supplements are being consumed. This is also an opportunity for the nurse to ask about any adverse reactions the patient may be experiencing from the medications. Polypharmacy may result from patients having multiple prescribers and pharmacies and patients continuing to take medications that have been discontinued by the doctor. Nurses are uniquely positioned to provide early diagnosis and intervention for potentially inappropriate medications and related adverse drug reactions. Project PurposePICO Question: Among elderly patients under care at Cary Medical Center on Med/Surg, who are currently taking multiple medications due to comorbidities, would reviewing medications at each provider visit reduce polypharmacy and associated adverse reactions? Currently, through observations and clinical experience on Med/Surg at Cary Medical Center, medications are administered by the nurse. Nurses are responsible and accountable for administering medications to patients. Bear with me......middle of the paper......due to the gap in the number of studies conducted on this topic. From the studies reviewed, the findings demonstrate that the increasingly health-related problem of polypharmacy among older adults requires the immediate attention of healthcare professionals. Studies have revealed that, together with medication reviews (brown bag), the STOPP criteria are a tool that can be effective in detecting PIMs. Studies have also revealed that nurses are in a position to address and evaluate adverse drug reactions associated with polypharmacy using the “brown bag,” medication review, and STOPP criteria. Regarding the PICO issue, the findings from these studies support the essential need for medication reviews by nurses and healthcare professionals at each provider visit to reduce the risk of polypharmacy and associated adverse reactions.