Polypharmacy among older adults is a growing concern in the U.S. healthcare system. Older adults who have comorbidities and take multiple medications are at greater risk for potential adverse drug reactions. Older adults who take over-the-counter medications, herbs, and supplements without consulting their doctor are at risk for adverse reactions associated with polypharmacy. Polypharmacy can result from patients having multiple prescribers and pharmacies and from patients continuing to take medications that have been discontinued by their doctor. There is a great need for nursing interventions regarding polypharmacy, including medication reviews also known as “brown bag.” As nurses obtain medical history data and conduct a patient assessment, it is essential to review patients' medications and ask open-ended questions regarding all types of medications the patient is taking. Additionally, the patient assessment also represents an opportunity for the nurse to inquire about any adverse reactions the patient may experience as a result of the medications. Nurses are uniquely positioned to provide early diagnosis and intervention for potentially inappropriate medications and related adverse drug reactions. Project PurposePICO Question: Among elderly patients under care at Cary Medical Center on Med/Surg, who are currently taking multiple medications due to comorbidities, would reviewing medications at each provider visit reduce polypharmacy and associated adverse reactions? Currently, through observations and clinical experience on Med/Surg at Cary Medical Center, medications are administered by the nurse. Nurses are responsible and accountable for administering medications to patients. The patient's pharmacological education is conducted by the nurse. Medication education includes informing the patient about the reason for the medication, when and for how long to take it, drug interactions, and the importance of consulting their primary care physician before taking any over-the-counter or herbal products. If the nurse is not familiar with a particular drug, a drug book is available for the nurse to use and gain knowledge about the drug's use, action, adverse reactions and contraindications. The method used to conduct the ROLA search for current peer-reviewed research studies using CINAHL, Medline, and PubMed was conducted. Search articles were generated using the search entry with the terms polypharmacy, polypharmacy among the elderly, adverse drug reactions and polypharmacy and consequences and polypharmacy. After receiving some research articles, a new search was conducted replacing the term polypharmacy with multiple medications. These searches yielded limited research articles related to the topic of polypharmacy.