The major spread of the disease is due to the trade route because people sometimes traded illegally and their product was not tested before being sold and fleas found in the fur of animals containing the virus of different diseases could easily spread. Colonization/imperialism created fear among the indigenous people as they were separated from their families and their culture was demolished. The missionary found the opportunity to spread Christianity by fueling the lies of their God and how disease spreads because of his anger at the wickedness and sins of people. The spread of the disease was involved in the warm climate which will help the development of the virus to grow and attack the immune system