Staphylococcus, enterococcus, and streptococcus are considered a major cause of many diseases. They are considered different due to their morphology. Staphylococci and streptococci acquire a round and spherical cell shape. On the other hand, the arrangement of cells is considered to be different for both organisms. For example, Staphylococcus aureus is a gram-positive cluster-forming coccus and non-spore-forming facultative anaerobe found in grape-like structures. Enterococci are also Gram-positive cocci with short chains and are considered facultative anaerobes. They can grow at temperatures between 10 and 45 degrees Celsius. Enterococcus is recognized as the main cause of nosocomial infections. Golden yellow colonies indicate that S. Aureus can ferment mannitol while Enterococcus and Streptococcus are unable to ferment mannitol. Furthermore, S. aureus is coagulase positive, having the ability to coagulate plasma, which makes it unique compared to other organisms. About 30% of humans carry S. aureus in the nose, back of the throat, or on the skin. The catalase test is also considered one of the major differences as strep is catalase positive while staph is catalase positive. Catalase is an enzyme that can destroy the dangerous chemical called hydrogen peroxide. Staphylococcus aureus is found in normal human flora. It is normally found in the nose and on the skin. It is known as one of the five most common causes of infections after recovering from an injury or surgery. It is transmitted through air droplets. For example, when an infected person coughs or sneezes, they tend to release small droplets of saliva into the air. The droplets contain bacteria and can infect… half the paper… puncture trauma, but may also be linked to the increased use of IVs and catheters, which are considered compromising devices. It is also responsible for urinary tract infections, bacteremia, endocarditis, meningitis and can be found in wound infections along with many other bacteria. Although more than 15 species occur in this genus, 80 to 90% of clinical isolates are Enterococcus faecalis. E. faecalis is known as the most antibiotic-resistant bacterium, making it the most pathogenic among other organisms. It contains many natural resistances to antibiotics, along with several acquired immunities transferred into R plasmids. Early diagnosis is important, especially if the infection is limited to the hospital environment. Vancomycin is the most effective antimicrobial agent in preventing E. faecalis infections, although resistance to this agent is becoming increasingly common.